Faculty and Staff Eric Masson: Department of Chemistry and Biochemistry: Ohio University

Department of Chemistry and Biochemistry: Faculty & Staff

Eric Masson

Contact Information

Office Location:	181 Clippinger Laboratories
Phone Number:	740-593-9992
Fax Number:	740-593-0148
E-Mail Address:	masson@ohio.edu

Assistant Professor
Ph.D. Swiss Federal Institute of Technology (ETH), Lausanne, Switzerland

Bioorganic and Supramolecular Chemistry

Courses Taught

Chemistry 480/580 Chemistry 705 Chemistry 307	Advanced Organic Chemistry Organometallic Chemistry Organic Chemistry	Offered Fall Quarter 08-09 Offered Winter Quarter 08-09 Offered Spring Quarter 08-09

POSTDOCTORAL FELLOW / RESEARCH ASSOCIATE POSITION IN SUPRAMOLECULAR CHEMISTRY

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Position available immediately

Focus is on the design, synthesis and evaluation of rotaxanes, catenanes, and other molecular machines.

Please see the details at http://www.phy.ohiou.edu/~eric/

Information

Research in the Masson group is at the crossroads of physical organic, bioorganic and medicinal chemistry. We are especially interested in host-guest supramolecular chemistry and in the mechanisms involved in non-covalent interactions. These interactions are tremendously important factors affecting the fascinating shape of large molecular assemblies such as proteins and DNA. Moreover, a myriad of non-covalent interactions between proteins play crucial roles in cellular pathways, such as growth and apoptosis regulation. Drug design also relies on such interactions to disrupt protein/protein or protein/DNA assemblies, in order to inhibit a specific cellular pathway.

Current projects include:

•    The construction of stimulus-sensitive nanostructures and molecular machines.
•    The design, synthesis and evaluation of new rotaxanes and other interlocked structures, and their applications as molecular machines.
•    The disruption of protein/protein interactions with new potent anti-cancer agents generated by dynamic combinatorial chemistry.
•    The synthesis and evaluation of planar substrates designed to bind to the minor groove of DNA. Applications will be oriented towards malaria treatment.
•    The elucidation and applications of the mysterious anion-pi interaction phenomenon. While such interactions have been shown to be highly favorable in silico, their existence in solution is yet to be demonstrated.
•    The regioselective functionalization of aromatic and heteroaromatic coumponds using “green polar organometallic chemistry” on solid phase

Department of Chemistry and Biochemistry
Clippinger Laboratories
Athens, OH 45701-2979
Tel: 740-593-1737 | Fax: 740-593-0148
chemistry@ohio.edu